What the Bible actually identifies
The word antichrist appears in John's letters, where it describes those who deny the truth about Jesus. John says there were already many antichrists at work in his own time. His test is about a person's response to Christ, not their appearance, personality, or sexual orientation (1 John 2:18, 1 John 2:22).
Paul also writes about a future rebellious figure often called the man of sin. This person resists God, exalts himself, and takes honour that belongs to God. Paul gives no statement about this person's sexual orientation (2 Thessalonians 2:3-4).
Little children, it is the last time: and as ye have heard that antichrist shall come, even now are there many antichrists; whereby we know that it is the last time.
The difficult prophecy behind the claim
People usually base this claim on a line in Daniel's vision about a proud king who rejects other objects of worship and magnifies himself above all. The immediate setting concerns conflict among rulers and kingdoms, and Christians have differed over whether the king refers chiefly to a ruler in Daniel's historical horizon, a future end-times opponent, or both as a pattern and fulfilment (Daniel 11:36-37).
The Hebrew wording in the disputed line is brief and difficult. It has been understood as referring to disregard for family loyalties, a particular religious devotion, marriage, or the king's complete contempt for anything that might limit his power. It does not plainly answer the modern question of whether he will be gay. It is wise to leave room for uncertainty where Scripture does.
Neither shall he regard the God of his fathers, nor the desire of women, nor regard any god: for he shall magnify himself above all.
Don't turn prophecy into a weapon
An unclear prophecy should never be used to imply that LGBTQ+ people are especially connected with evil or end-times deception. Every person is made in God's image, and Jesus calls his followers to love their neighbours (Genesis 1:27, Matthew 22:39).
Christians hold different convictions about sexuality, but none of those convictions permits cruelty, mockery, or suspicion towards people. The New Testament's call to repentance and new life is for everyone. Paul reminded the divided believers in Corinth that their cleansing and new identity came through Jesus, not through superiority over others (1 Corinthians 6:11).
Keep your focus on Jesus
Jesus warned that false christs and false prophets may appear convincing. The key question is not whether a future deceiver fits a list of imagined personal traits. Ask whether a message pulls people away from Jesus, his truth, and his lordship (Matthew 24:24-25).
John gives the same practical direction: test spiritual claims by what they confess about Jesus Christ. The Bible's concern about the Antichrist is rebellion against Christ and deception of others, not a stated sexual orientation. Read prophecy humbly, and keep holding on to what Scripture makes clear (1 John 4:1-3).
Let no man deceive you by any means: for that day shall not come, except there come a falling away first, and that man of sin be revealed, the son of perdition; Who opposeth and exalteth himself above all that is called God, or that is worshipped; so that he as God sitteth in the temple of God, shewing himself that he is God.